Mümkündür... php-mysql ile sadece veri kontrolü yaparsın gerisi player'a kalmış... Bazı html5 player'lar dediğini yapıyor. Örn: Acorn Media Player, Accessible and customizable HTML5 media player (http://ghinda.net/acornmediaplayer/) :)
<video width="826" height="352" preload="metadata" aria-describedby="full-descript" tabindex="0" id="acorn1334854049582" data-width="826" data-height="352" class="">
<source src="http://mokush.bitbucket.org/acornmedia/Elephants_Dream_320.mp4">
<source src="http://mokush.bitbucket.org/acornmedia/Elephants_Dream_320.webm">
<track src="subs/afrikaans.srt" kind="subtitles" srclang="en" label="Afrikaans"></track>
<track src="subs/arabic.srt" kind="subtitles" srclang="de" label="Arabic"></track>
<track src="subs/brazilian.srt" kind="subtitles" srclang="es" label="Brazilian"></track>
<track src="subs/bulgarian.srt" kind="subtitles" srclang="fr" label="Bulgarian"></track>
<track src="subs/chinese.srt" kind="subtitles" srclang="it" label="Chinese"></track>
<track src="subs/french.srt" kind="subtitles" srclang="nl" label="French"></track>
<track src="subs/hungarian.srt" kind="subtitles" srclang="pl" label="Hungarian"></track>
<track src="subs/romanian.srt" kind="subtitles" srclang="pt" label="Romanian"></track>
<track src="subs/spanish.srt" kind="subtitles" srclang="pt" label="Spanish"></track>
You can download Elephant's Dream at <a href="http://orange.blender.org/">orange.blender.org</a>.
</video>
gibi <track> ile altyazı dosyalarını videoya ekletebilirsin... Yalnız belirtmekte fayda var, şuan tüm tarayıcılar html5 desteklemiyor ;) (Chrome + Firefox 4+ da sorun yok, IE,Safari ve Opera'da sorun vardı en son hatırladığım)